Establishment of an analytical method for butaphosphan (BTP), a stress-attenuating agent, and its application in the preliminary pharmacokinetic evaluation of residues in olive flounder Paralichthys olivaceus

Table 4 Pharmacokinetic parameters for muscle BTP level changes after intramuscular injection in olive flounder

Parameters	Units	13 ± 3 °C		22 ± 3 °C
Parameters	Units	50 mg/kg	150 mg/kg	50 mg/kg	150 mg/kg
k₁₂	day⁻¹	2.103	2.406	2.178	1.474
k₂₁	day⁻¹	0.322	0.462	0.196	0.553
C_max	mg/kg	1.662	4.428	1.456	3.219
T_max	days	0.150	0.121	0.246	0.071
t_1/2E	days	7.131	8.372	8.296	7.002
V_d	L	13.5	23.743	13.477	40.826
V_d2	L	149.466	123.763	149.466	108.798
Cl	L/day	19.171	14.452	22.863	17.160
AUC_0-∞	mg/kg·day	2.608	10.379	2.187	8.741
AUCM	mg/kg·day²	19.725	106.512	16.086	76.403
MRT_0-∞	days	7.563	10.262	7.356	8.740

k₁₂ rate constant to central compartment, k₂₁ rate constant to peripheral compartment, Vd volume of distribution, C_max maximum concentration, T_max time reaching maximum concentration, t_1/2E half-life for elimination, V_d central volume of distribution, V_d2 peripheral volume of Cl, clearance; AUC_0-∞ area-under-the-time curve, AUMC area-under-the-moment curve, MRT_0-∞ mean residence time from zero to infinity, n = 10 for each parameter

ISSN: 2234-1757