Establishment of an analytical method for butaphosphan (BTP), a stress-attenuating agent, and its application in the preliminary pharmacokinetic evaluation of residues in olive flounder Paralichthys olivaceus

Table 3 Pharmacokinetic parameters for plasma BTP level changes after intramuscular injection in olive flounder

Parameters	Units	13 °C ± 3 °C		22 °C ± 3 °C
Parameters	Units	50 mg/kg	150 mg/kg	50 mg/kg	150 mg/kg
C_max	mg/L	6.910	22.623	5.445	5.445
T_max	days	1.000	1.000	0.042	1.000
t_1/2E	days	1.877	2.220	1.363	1.977
V_d	L	5.751	6.601	10.188	16.479
Cl	L/day	2.124	2.061	5.180	5.779
AUC_0-∞	mg/L·day	23.539	72.785	9.653	25.957
MRT_0-∞	days	2.674	2.927	1.382	1.970
AUMC_0-∞	mg/L·day²	62.954	213.075	13.339	51.147

C_max maximum concentration, T_max time reaching maximum concentration, t_1/2E half-life for elimination phase, V_d volume of distribution, Cl clearance, AUC_0-∞ area-under-the-time curve to infinity, AUMC_0-∞ area-under-the-moment curve to infinity, MRT_0-∞ mean residence time to infinity, n = 5 for each parameter

ISSN: 2234-1757