Fig. 4From: Padina boryana, a brown alga from the Maldives: inhibition of α-MSH-stimulated melanogenesis via the activation of ERK in B16F10 cellsEffect of P. boryana ethanolic extract on melanoma cells against specific ERK inhibitor. a ERK pathway associated protein and c tyrosinase expression in α-MSH-stimulated B16F10 cells. Cells were incubated with α-MSH with PBE in the absence or presence of ERK-specific inhibitor, PD98059. Protein expressions were analyzed by Western blotting, b, d relevant quantitative data. Data points and bars represent the means ± SD (n = 3) (*p < 0.05; **p < 0.01) (number sign denotes significance compared to control while asterisk represents significance compared to the α-MSH-treated group)Back to article page