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Table 2 Inhibitory activity of HSS and its solvent-soluble fractions on the expression of ICAM-1 and VCAM-1 in TNF-α-stimulated HUVECs

From: Hexane fraction from the ethanolic extract of Sargassum serratifolium suppresses cell adhesion molecules via regulation of NF-κB and Nrf2 pathway in human umbilical vein endothelial cells

Fractions IC50 (μg/mL)a Yields (%)c
ICAM-1b VCAM-1b
Ethanolic extract 7.25 ± 0.53 6.67 ± 0.31 100 ± 5.2
n-Hexane 4.55 ± 0.52 3.61 ± 0.22 66.1 ± 4.3
Ethyl acetate 2.29 ± 0.13 4.53 ± 0.28 9.23 ± 1.2
n-Butanol ≥ 100 ≥ 100 17.5 ± 1.9
Water ≥ 100 ≥ 100 8.12 ± 1.4
  1. aIC50 is calculated to be concentrations with a half-maximal expression of ICAM-1 and VCAM-1 in TNF-α-stimulated HUVECs
  2. bThe expression of levels of ICAM-1 and VCAM-1 were determined with Western blot
  3. cYield is showing the amount of each fraction in 100 g of ethanolic extract