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Table 2 Inhibitory activity of HSS and its solvent-soluble fractions on the expression of ICAM-1 and VCAM-1 in TNF-α-stimulated HUVECs

From: Hexane fraction from the ethanolic extract of Sargassum serratifolium suppresses cell adhesion molecules via regulation of NF-κB and Nrf2 pathway in human umbilical vein endothelial cells

Fractions

IC50 (μg/mL)a

Yields (%)c

ICAM-1b

VCAM-1b

Ethanolic extract

7.25 ± 0.53

6.67 ± 0.31

100 ± 5.2

n-Hexane

4.55 ± 0.52

3.61 ± 0.22

66.1 ± 4.3

Ethyl acetate

2.29 ± 0.13

4.53 ± 0.28

9.23 ± 1.2

n-Butanol

≥ 100

≥ 100

17.5 ± 1.9

Water

≥ 100

≥ 100

8.12 ± 1.4

  1. aIC50 is calculated to be concentrations with a half-maximal expression of ICAM-1 and VCAM-1 in TNF-α-stimulated HUVECs
  2. bThe expression of levels of ICAM-1 and VCAM-1 were determined with Western blot
  3. cYield is showing the amount of each fraction in 100 g of ethanolic extract
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Fisheries and Aquatic Sciences

ISSN: 2234-1757

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