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Table 4 Fractional inhibitory concentration (FIC) of antibiotics in combination with Hexane-soluble fraction of Ishige okamurae against antibiotic-resistant Pseudomonas aeruginosa

From: Antibacterial effect of Ishige okamurae extract against cutaneous bacterial pathogens and its synergistic antibacterial effect against Pseudomonas aeruginosa

Strains

Test compound

MIC (μg/mL)

∑FICmax

∑FICmin

Median ∑FIC

Minimum concentration for observing synergy

P. aeruginosa

KCTC 1637

Hexane

64

1.06

0.31

0.57

8

Ceftazidime

8

2

Hexane

64

1.06

0.52

0.63

8

Meropenem

16

4

P. aeruginosa

isolate 4068

Hexane

64

1.00

0.31

0.50

4

Ceftazidime

16

4

Hexane

64

1.06

0.38

0.57

8

Ciprofloxacin

16

4

Hexane

64

1.50

0.52

0.75

16

Meropenem

16

4

P. aeruginosa

isolate 4135

Hexane

128

1.13

0.38

0.63

16

Ceftazidime

8

2

Hexane

128

1.25

0.31

0.63

16

Ciprofloxacin

16

4

P. aeruginosa

isolate 4561

Hexane

128

1.00

0.38

0.52

8

Ceftazidime

16

4

Hexane

128

1.06

0.38

0.50

8

Ciprofloxacin

16

2

Hexane

128

1.13

0.50

0.75

32

Meropenem

16

8

  1. The FIC index indicated synergistic effect: < 0.5, marked synergy; 0.5 to < 1.0, weak synergy; 1.0, additive; > 1.0 to < 2.0, subadditivie; 2.0, indifferent; > 2.0, antagonistic
  2. ∑FIC max maximum FIC, ∑FIC min minimum FIC, ∑FIC med medium FIC