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Table 1 Bioassay of degradation activity of TEM-52 enzyme against various classes of antimicrobials

From: A novel method to depurate β-lactam antibiotic residues by administration of a broad-spectrum β-lactamase enzyme in fish tissues

Class

Antimicrobials

Inhibition zone (mm, mean ± SD)

Control drug disk

TEM-52-treated drug disk

β-Lactam

Cefotaxime

9.3 ± 0.6

0.0 ± 0.0

Cefazolin

6.0 ± 1.7

2.3 ± 1.2

Penicillin G

8.0 ± 0.6

0.0 ± 0.0

Amoxicillin

8.7 ± 0.6

0.0 ± 0.0

Pivampicillin

7.3 ± 0.6

0.0 ± 0.0

Tetracycline

Oxytetracycline

9.8 ± 0.9

9.7 ± 0.6

Quinolone

Ciprofloxacin

8.2 ± 0.0

8.0 ± 0.4

Macrolide

Erythromycin

10.0 ± 1.0

10.0 ± 2.0

Josamycin

8.6 ± 0.6

8.7 ± 0.5

Aminoglycoside

Streptomycin

8.5 ± 0.4

8.7 ± 0.6

  1. Concentrations of antimicrobials in incubation were adjusted to produce 6–11 mm clear zones beyond the disk areas (0.5–500 μg/disk)
  2. Triplicate determinations
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Fisheries and Aquatic Sciences

ISSN: 2234-1757

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