Fig. 1

In vivo and ex vivo cefazolin degradation activity of TEM-52 in carp. a–c In vivo cefazolin changes in serum (a), liver, (b) and muscle (c) following intraperitoneal injection of TEM-52, N = 5–10; filled bar, control carp; shaded bar, TEM-52-injected carp (d) ex vivo cefazolin changes when TEM-52-injected carp serum were incubated with cefazolin, N = 5; filled bar, without enzyme; shaded bar, incubated with TEM-52 itself or TEM-52-injected carp serum. *p < 0.05 with unpaired t tests when compared to control groups