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Fig. 3 | Fisheries and Aquatic Sciences

Fig. 3

From: Gliotoxin from the marine fungus Aspergillus fumigatus induces apoptosis in HT1080 fibrosarcoma cells by downregulating NF-κB

Fig. 3

Gliotoxin inhibits activation of NF-κB by suppressing the phosphorylation and degradation of IκB-α. HT1080 cells were treated with various concentrations (0 to 100 μM) of gliotoxin for 24 h, and the cytosol and nuclear lysates were subjected to immunostaining for the p65 subunit of NF-κB, phosphorylated IκB-α, total IκB-α, α-tubulin, and lamin B (a). The immunoblot signals were quantified. Each value was expressed as the mean ± SD of a triplicate experiment. *P < 0.05 compared to the control without gliotoxin treatment (b)

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